Yankees vs. Red Sox: April 22 MLB Predictions

The New York Yankees are set to face off against the Boston Red Sox in the second game of their three-game series on April 22, 2026. After a convincing 4-0 victory over the Red Sox on Tuesday, the Yankees will aim to extend their winning streak to five games. Currently leading the American League East with a record of 14-9, the Yankees have shown strong performance on the road, boasting a 6-4 record this season. In contrast, the Red Sox, struggling with a 9-14 record, have lost three of their last four games and are 5-6 at home this year.

On the mound for New York will be Max Fried, who holds a 2-1 record with a 2.97 ERA. The Red Sox will counter with Ranger Suarez, who has a 1-1 record and a 3.22 ERA. The first pitch is scheduled for 6:45 p.m. ET at Fenway Park in Boston. According to the latest odds, the Yankees are favored at -134 on the money line, meaning a bet of $134 would yield a profit of $100 if they win. The over/under for the game is set at 7.5 runs.

Before placing any bets, it's crucial to consider the insights from SportsLine's proven computer model, which has simulated the game 10,000 times. Last season, the model achieved a profitable 35-29 record on top-rated MLB money-line picks and excelled in home run prop bets, returning nearly 30 units of profit. This season, the model has identified key predictions for the Yankees vs. Red Sox matchup, including expectations for total runs and individual player performances.

The model predicts that the total combined runs will exceed 7.5, as the over has cleared in six of the last ten games for Boston. The Yankees have been particularly strong offensively, ranking ninth in MLB with 114 runs scored, while the Red Sox's pitching staff ranks 22nd, allowing an average of 4.40 earned runs per game. Notable players to watch include Aaron Judge, Cody Bellinger, and Giancarlo Stanton for the Yankees, all projected to achieve over 1.5 total bases. For the Red Sox, Roman Anthony and Jarren Duran are expected to contribute significantly.

As the game approaches, bettors should keep an eye on the latest odds and predictions from SportsLine to make informed decisions. With the Yankees looking to maintain their momentum and the Red Sox desperate for a turnaround, this matchup promises to be an exciting clash in the MLB schedule.