Oklahoma vs. Michigan Prediction for College Football Week 2

The Michigan Wolverines hosted the No. 11 Oklahoma Sooners on Saturday in a Week 2 Big Noon Kickoff matchup on FOX. In one of the most dramatic endings in college football history, Michigan converted a miraculous Hail Mary to avoid a massive upset against Western Michigan in Week 1. The Wolverines originally thought they had lost before replay review put one second back on the clock, giving them one final chance to throw a Hail Mary. They took advantage of the opportunity. Despite the win, the Kyle Whittingham era got off to a rocky start as the Wolverines barely escaped a Western Michigan team that entered the game as 27.5-point underdogs. Bryce Underwood and the offense struggled mightily, managing just 13 points, 12 first downs, and 276 total yards. Still, Michigan was 1-0 and had a huge opportunity to flip the script against a ranked opponent in Week 2. Meanwhile, Oklahoma's Week 1 opener went much more smoothly. The Sooners cruised past UTEP 51-0, with John Mateer throwing for 225 yards and three touchdowns. Oklahoma's defense also picked up right where it left off in 2025, shutting out UTEP after finishing the previous season as one of the best units in the country. As of September 12, here are the odds for Oklahoma vs. Michigan at FanDuel Sportsbook: Oklahoma Moneyline: -215 (bet $10 to win $10.25 total) Michigan Moneyline: +176 (bet $10 to win $27.60 total) Spread: Oklahoma -5.5 : -110 (bet $10 to win $19.09 total) Michigan +5.5: -110 (bet $10 to win $19.09 total) Over/Under: Over 43.5 : -110 (bet $10 to win $19.09 total) Under 43.5 : -110 (bet $10 to win $19.09 total) In Week 1, Michigan turned the ball over three times while failing to force a single takeaway. Underwood struggled through the air, completing just 12 of 23 passes (52.2%) for 170 yards and an interception. The Wolverines also struggled on third down, converting just 3 of 10 attempts (30%), compared to Western Michigan's 8-of-18 mark (44.4%). Thus, Oklahoma may seem like the obvious play. However, this is college football, and in a significant game like this, the edge typically goes to the home team. The betting markets appeared to be overreacting to Michigan's poor Week 1 performance. Whittingham would likely have his team ready to bounce back, as it seemed possible that the Wolverines were looking ahead to this matchup and did not rise to the occasion against a MAC opponent. That would not be the case on Saturday, as Michigan would be prepared for a ranked opponent and a Big Noon Kickoff showdown in front of its home crowd. Therefore, backing the Wolverines to bounce back and cover the spread would be a solid pick.