Yankees vs. Red Sox prediction, odds, time for Game 2

The New York Yankees looked to close out their American League Wild Card series against the Boston Red Sox in Game 2 on Wednesday night during the 2026 MLB playoffs. New York opened the series with a dominating 9-0 victory over Boston on Tuesday. The Red Sox, finishing third in the AL East with a record of 87-75, entered the game having lost two consecutive matches and held a 46-36 record on the road in 2026. Meanwhile, the Yankees, placing second in the division with a 93-68 record, aimed to continue their momentum after winning their last two games and were 47-34 at home this season.

Sonny Gray, boasting an 18-5 record and a 2.72 ERA, was set to start for Boston. The New York team countered with left-hander Max Fried, who had a 5-5 record and a 2.80 ERA. The first pitch from Yankee Stadium in New York was scheduled for 8 p.m. ET. In the latest Yankees vs. Red Sox odds, New York was favored at -134 (risking $134 to win $100), while the over/under set for the game was 6.5 runs.

Before placing any bets on the Red Sox vs. Yankees game, fans were advised to review predictions and betting advice from SportsLine's proven computer model. This model had simulated the matchup 10,000 times, entering the 2026 MLB playoffs with a 31-25 track record on top-rated MLB money-line picks at various betting sites, yielding over $900 in returns for players who had deposited $100. With strong returns in previous games, the model focused on the Red Sox vs. Yankees matchup and locked in its predictions and picks.

In detail, the Yankees had established a money line of -134 against the Red Sox's +120. The over/under for combined runs between the teams was set at 6.5. Additionally, the Yankees were favored by -1.5 runs at +168 in the run line. The game was expected to be broadcasted through various streaming services.