Cardinals vs. Marlins: April 22 MLB Predictions

On April 22, 2026, the St. Louis Cardinals will face off against the Miami Marlins in the final game of a three-game series at loanDepot Park in Miami. The Cardinals, currently holding a record of 14-9, are looking to extend their winning streak to three games, while the Marlins, at 11-13, aim to break their series losing streak after dropping the second game of the series 5-3.

The Marlins started strong by winning the first game of the series but faltered in the second, showcasing their struggles to maintain momentum. Janson Junk (0-2, 4.50 ERA) is set to take the mound for Miami, while St. Louis will counter with Kyle Leahy (2-2, 5.21 ERA). Both pitchers have faced challenges this season, with Junk's recent performances raising concerns about his ability to keep runs off the board.

According to the latest odds, the Marlins are favored at -134 on the money line, meaning a bet of $134 would yield a $100 profit if they win. The over/under for total runs in the game is set at 8.5, reflecting expectations for a potentially high-scoring affair. Sports analysts suggest that both teams have shown tendencies to lean towards the over in their recent games, making this matchup particularly intriguing for bettors.

The SportsLine Projection Model, which has successfully predicted MLB outcomes in the past, has simulated this game 10,000 times. The model indicates that the total combined runs are likely to exceed 8.5, with an average projection of 9.9 runs. This prediction is bolstered by the fact that both starting pitchers have ERAs above 4.50, suggesting that runs may come easily.

In the last ten games, the Cardinals have demonstrated a strong offensive presence, with a 7-3 record favoring the over. Meanwhile, the Marlins have also shown a propensity for scoring, particularly after their initial struggles at the start of the season. As both teams prepare for this crucial game, fans and bettors alike will be keenly watching to see if the Cardinals can continue their winning ways or if the Marlins can turn their fortunes around.