Yankees vs. Red Sox: April 22 MLB Predictions

The New York Yankees are set to face off against the Boston Red Sox in the second game of their three-game series on Wednesday night, April 22, 2026. After a decisive 4-0 victory over the Red Sox on Tuesday, the Yankees are looking to extend their winning streak to five games. Currently leading the American League East with a record of 14-9, the Yankees have shown strong performance on the road, boasting a 6-4 record this season.

On the other hand, the Red Sox, with a record of 9-14, are struggling, having lost three of their last four games. They have a home record of 5-6 in 2026, which adds pressure as they prepare to host the Yankees at Fenway Park. The starting pitchers for this matchup are Max Fried for the Yankees, who holds a 2-1 record with a 2.97 ERA, and Ranger Suarez for the Red Sox, who is 1-1 with a 3.22 ERA.

The first pitch is scheduled for 6:45 p.m. ET, and the Yankees are currently favored at -142 on the money line, meaning a bet of $142 would yield a profit of $100 if they win. The over/under for the game is set at 7.5 runs.

Before placing any bets on the Yankees vs. Red Sox game, it’s essential to consult the predictions and betting advice from SportsLine’s proven computer model. This model has simulated the game 10,000 times and has a solid track record, finishing last season with a profitable 35-29 on top-rated MLB money-line picks.

In terms of scoring, the Yankees have been one of the more potent offenses in the league, ranking ninth in total runs scored with 114. Conversely, the Red Sox's pitching staff has struggled, allowing an average of 4.40 earned runs per game, ranking them 22nd in the league.

The model predicts that the total runs scored in this game will exceed the over/under of 7.5, as it has cleared in six of the last ten games for Boston. Key players to watch include Aaron Judge, Cody Bellinger, and Giancarlo Stanton for the Yankees, while Roman Anthony and Jarren Duran are expected to make significant contributions for the Red Sox.

With the model projecting a total of 9.4 combined runs, the over is favored in 65% of the simulations. For those looking to make informed bets, SportsLine offers detailed insights and predictions based on extensive simulations. Make sure to check out their analysis before finalizing your picks for this exciting matchup.